(S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole

CAS: 14769-73-4

Ref. 3D-FL138922

Product Information

• Name: (S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole
• Synonyms: Levamisole, (-)-2,3,5,6-Tetrahydro-6-phenylimidazo[2.1-b]thiazole, (-)-Tetramisole, (6S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole, (6S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole, (6S)-6-Phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole, (S)-(-)-Levamisole, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole, <span class="text-smallcaps">L</span>-Tetramisole, Anthelsol, Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (S)-, Ketrax, Lepuron, Levamisol, Levipor, Levomol, Levomysol, Levovermax, Nilverm LV, Totalon, Vermisol 150, Wormicid, l-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole, l-Tetramisole
• CAS: 14769-73-4

Description

The drug, 2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole (TEM), is a small molecule with potent immunomodulatory properties. TEM is a competitive inhibitor of the enzyme histamine N-methyltransferase and inhibits the synthesis of histamine and other proinflammatory mediators. It also has anthelmintic activity against nematodes and exhibits anti-inflammatory activities in animal models of autoimmune diseases such as lupus erythematosus and inflammatory skin diseases such as psoriasis. TEM is also a potent inhibitor of lymphocyte transformation. This drug can be used for the treatment of chronic viral hepatitis, which is caused by hepatitis B or C virus infections. TEM binds to the active site on the enzyme RNA polymerase II that catalyzes DNA transcription to produce messenger RNA. TEM blocks RNA synthesis by binding to the template strand of DNA, preventing

• Brand: Biosynth

Chemical properties

• Molecular weight: 204.29 g/mol
• Formula: C₁₁H₁₂N₂S
• Purity: Min. 97 Area-%
• Color/Form: Powder
• InChI: InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
• InChI key: InChIKey=HLFSDGLLUJUHTE-SNVBAGLBSA-N
• SMILES: c1ccc([C@H]2CN3CCSC3=N2)cc1