Lapatinib ditosylate monohydrate
CAS: 388082-78-8
Ref. 3D-FL24843
| 5g | 234.00 € | ||
| 10g | 352.00 € | ||
| 25g | 509.00 € | ||
| 50g | 746.00 € | ||
| 100g | 1,123.00 € |
Product Information
- N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine bis(4-meth ylbenzenesulfonate) ditosylateGW-572016F ditosylateTykerb ditosylate
Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.
Chemical properties
Technical inquiry about: 3D-FL24843 Lapatinib ditosylate monohydrate
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