Larotaxel

CAS: 156294-36-9

Ref. 3D-FL24844

Product Information

• Name: Larotaxel
• Synonyms: (a-R,, PNU 100940, Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (1S,2S,4S,7R,8aR,9aS,10aR,12aS,12bR)-7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2H-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl ester, (αR,βS)-, Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (1S,2S,4S,7R,8aR,9aS,10aR,12aS,12bR)-7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2H-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl ester, Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2H-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl ester, [1S-[1α,2α,4α(αS*,βR*),7β,8aS*,9aα,10aα,12aα,12bα]]-

Description

Larotaxel is a taxane drug that is used to treat solid tumours. It has been shown to be effective against her2+ breast cancer and mcl-1 protein positive cells. Larotaxel binds to the mcl-1 protein, which is a potential drug target in the development of cancer treatments. The effect of larotaxel on cell proliferation can be measured by the concentration-time curve and it has been shown to inhibit ATP-binding cassette transporter activity. Larotaxel has also been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 831.9 g/mol
• Formula: C₄₅H₅₃NO₁₄
• Purity: Min. 95%