5-(Methoxymethyl)quinolin-8-ol

CAS: 7545-59-7

Ref. 3D-FM133009

Product Information

• Name: 5-(Methoxymethyl)quinolin-8-ol
• Synonyms: 8-quinolinol, 5-(methoxymethyl)-

Description

5-(Methoxymethyl)quinolin-8-ol is a potent inhibitor of the enzyme phosphodiesterase 4 that is used in the treatment of pulmonary hypertension. It has been shown to have an optimum concentration of 1.25 μM, as measured by electrochemical impedance spectroscopy. This molecule also inhibits phosphodiesterase 2 and 3, with an IC50 value of 0.5 μM and 0.9 μM, respectively. 5-(Methoxymethyl)quinolin-8-ol has been found to be polymorphic and its crystal structure has been determined using X-ray diffraction analysis. The compound is soluble in water and exhibits a constant kinetic profile for the hydrolysis reaction with a rate constant of 2 × 10 M/s at 25 °C. In addition, it has potentiodynamic polarization properties and can be used for microscopy studies due to its ability to bind to proteins and polysaccharides on the cell surface.

• Brand: Biosynth

Chemical properties

• Molecular weight: 189.21 g/mol
• Formula: C₁₁H₁₁NO₂
• Purity: Min. 95%
• InChI: InChI=1S/C11H11NO2/c1-14-7-8-4-5-10(13)11-9(8)3-2-6-12-11/h2-6,13H,7H2,1H3
• InChI key: InChIKey=YNADRYIGLPRUCC-UHFFFAOYSA-N
• SMILES: COCc1ccc(O)c2ncccc12