Methyl 6-oxohexahydropyridazine-4-carboxylate

CAS: 153895-80-8

Ref. 3D-FM136931

Product Information

• Name: Methyl 6-oxohexahydropyridazine-4-carboxylate
• Synonyms: 4-pyridazinecarboxylic acid, hexahydro-6-oxo-, methyl ester

Description

Methyl 6-oxohexahydropyridazine-4-carboxylate is a potent inhibitor of the enzyme dimethylhydrazine carboxylase (DMH). This enzyme catalyses the formation of DMH from hydrazine and methyl acetoacetate. DMH is an intermediate in the metabolism of nitrogenous compounds, such as amino acid, purines and pyrimidines. Methyl 6-oxohexahydropyridazine-4-carboxylate inhibits the conversion of DMH to carbonyl cyanide 4-(trichloromethyl)phenylhydrazone (CCCP), which is a powerful uncoupling agent that causes heat production by uncoupling oxidative phosphorylation. Methyl 6-oxohexahydropyridazine-4-carboxylate also inhibits protein synthesis by preventing the formation of ATP.

• Brand: Biosynth

Chemical properties

• Molecular weight: 158.16 g/mol
• Formula: C₆H₁₀N₂O₃
• Purity: Min. 95%
• InChI: InChI=1S/C6H10N2O3/c1-11-6(10)4-2-5(9)8-7-3-4/h4,7H,2-3H2,1H3,(H,8,9)
• InChI key: InChIKey=DLDWDQWZWAVSJB-UHFFFAOYSA-N
• SMILES: COC(=O)C1CNNC(=O)C1