1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide

CAS: 109889-09-0

Ref. 3D-FM137557

Product Information

• Name: 1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide
• Synonyms: Granisetron, 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide, 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, endo-, 1H-Indazole-3-carboxamide, 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, 9-Azabicyclo[3.3.1]nonane, 1H-indazole-3-carboxamide deriv., Apf 530, Brl 43694, Brl 43964, Granisetron free base, Kevatril, Sancuso, Sustol, endo-Granisetron

Description

1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide is a chemical inhibitor of the 5HT2 receptor, which is responsible for regulating nausea and vomiting. It has been shown to have antiemetic properties, and can be used in chemotherapy to control nausea and vomiting. The 5HT2 receptor is coupled to Gs proteins and inhibits adenylyl cyclase activity, while 1MMAI binds to the 5HT2A receptor and blocks serotonin from binding. This prevents serotonin from activating Gq protein receptors, which are involved in the generation of intracellular calcium concentrations that lead to neurotransmitter release. 1MMAI also inhibits the activation of phospholipase C by serotonin, resulting in decreased levels of diacylglycerol (DAG) and inositol triphosphate (IP3). These changes inhibit plate

• Brand: Biosynth

Chemical properties

• Molecular weight: 312.41 g/mol
• Formula: C₁₈H₂₄N₄O
• Purity: Min. 95%
• Color/Form: White Off-White Powder