5-Methoxy-3,4-dihydronaphthalen-1(2H)-one

CAS: 33892-75-0

Ref. 3D-FM140596

Product Information

• Name: 5-Methoxy-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 1(2H)-Naphthalenone, 3,4-dihydro-5-methoxy-, 3,4-Dihydro-5-methoxy-1(2H)-naphthalenone, 5-Methoxy-1,2,3,4-Tetrahydronaphthalen-1-One, 5-Methoxy-1,2,3,4-tetrahydro-1-oxonaphthalene, 5-Methoxy-3,4-dihydro-2H-naphthalen-1-one, 5-Methoxy-α-tetralone, 5-Methoxytetralone, NSC 310000
• CAS: 33892-75-0

Description

5-Methoxy-3,4-dihydronaphthalen-1(2H)-one is a hydrogenation reduction product of 5-methoxyindole and has been synthesized by the addition of a chloroformate to an alkene. This compound has been shown to have potent inhibitory activity against the enzyme cholesteryl ester hydrolase. The absolute configuration was determined by X-ray diffraction data and is homochiral. It is an analog of naphthol, a biologically active compound that is used as an intermediate in the synthesis of compounds such as naphthylacetic acid and naphthohydroquinone. The bioassay showed that this compound is a potent inhibitor with an IC50 value of 5 μM.

• Brand: Biosynth

Chemical properties

• Molecular weight: 176.21 g/mol
• Formula: C₁₁H₁₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C11H12O2/c1-13-11-7-3-4-8-9(11)5-2-6-10(8)12/h3-4,7H,2,5-6H2,1H3
• InChI key: InChIKey=BRCPWISABURVIH-UHFFFAOYSA-N
• SMILES: COc1cccc2c1CCCC2=O