5-Methylpyridine-3-carbohydrazide
CAS: 808127-97-1
Ref. 3D-FM166574
25mg | Discontinued | ||
50mg | Discontinued | ||
100mg | Discontinued | ||
250mg | Discontinued | ||
500mg | Discontinued |
Product Information
5-Methylpyridine-3-carbohydrazide is an important chiral intermediate that is used in the synthesis of sulfonamides. The compound can be prepared by a process called the Corey-Chaykovsky reaction, which involves the addition of methyl acetoacetate to 3-hydroxybenzaldehyde. This process is a bottleneck in the synthesis of sulfonamides due to its lack of stereospecificity and high reactivity with water. It has been shown that 5-methylpyridine-3-carbohydrazide can be synthesized using a more effective process, such as one involving the use of sodium metal and methylformamide.