1-Methyl-D-tryptophan

CAS: 110117-83-4

Ref. 3D-FM167977

Product Information

• Name: 1-Methyl-D-tryptophan
• Synonyms: 1-Methyl-D-Trp, Indoximod
• CAS: 110117-83-4

Description

1-Methyl-D-tryptophan (1MT) is a metabolite of tryptophan. It has been shown to inhibit the enzyme IDO1, which is involved in the production of tumor necrosis factor (TNF), and to possess immunomodulatory effects. 1MT may be useful for the treatment of cancer, as it has been shown to inhibit growth and induce apoptosis in human liver and brain tumor cells, as well as in human leukemia cells. 1MT also inhibits the proliferation of myeloid-derived suppressor cells and increases their sensitivity to cytotoxic drugs.

• Brand: Biosynth

Chemical properties

• Molecular weight: 218.25 g/mol
• Formula: C₁₂H₁₄N₂O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
• InChI key: InChIKey=ZADWXFSZEAPBJS-SNVBAGLBSA-N
• SMILES: Cn1cc(C[C@@H](N)C(=O)O)c2ccccc21