R-(-)-Manidipine

CAS: 133082-19-6

Ref. 3D-FM25012

Product Information

• Name: R-(-)-Manidipine
• Synonyms: (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (-)-Manidipine, (-)-Manidipine, (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (4R)-, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (4R)- (9CI), 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (R)-, O3-[2-(4-benzhydrylpiperazin-1-yl)ethyl] O5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Description

R-(-)-Manidipine is a chiral compound that is metabolized in the body to form two enantiomers, (+)- and (-)-manidipine. The pharmacokinetic study of R-(-)-Manidipine was conducted by comparing the plasma concentrations of the racemic mixture with those of the individual enantiomers. The diastereomeric ratios were determined by analyzing plasma samples using a mass spectrometer and reaction monitoring. The pharmacokinetic study showed that both enantiomers have antihypertensive activity, but (-)-manidipine has higher potency than (+)-manidipine.

• Brand: Biosynth

Chemical properties

• Molecular weight: 610.7 g/mol
• Formula: C₃₅H₃₈N₄O₆
• Purity: Min. 95%