Methyl 7-azaindole-3-glyoxylate

CAS: 357263-49-1

Ref. 3D-FM25463

Product Information

• Name: Methyl 7-azaindole-3-glyoxylate
• Synonyms: Methyl (7-azaindol-3-yl)oxoacetatea-Oxo-1H-pyrrolo[2,3-b]pyridine-3-acetic acid methyl ester(Oxo)(1H-pyrrolo[2,3-b]pyridin-3-yl)ac etic acid methyl ester, (Oxo)(1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid methyl ester, 1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, α-oxo-, methyl ester, Methyl (7-azaindol-3-yl)oxoacetate, Methyl α-oxo-1H-pyrrolo[2,3-b]pyridine-3-acetate, methyl oxo(1H-pyrrolo[2,3-b]pyridin-3-yl)acetate

Description

Methyl 7-azaindole-3-glyoxylate is a potent inhibitor of glycogen synthase kinase-3 (GSK-3). GSK-3 is an enzyme that phosphorylates glycogen synthase and inhibits its activity. This inhibitor has been shown to be selective for GSK-3β, with no inhibitory effect on other protein kinases such as protein kinase A or C. Methyl 7-azaindole-3-glyoxylate is a cyclic compound that binds to the ATP binding site of the GSK-3β enzyme, preventing the release of phosphate from ATP and inhibiting glycogen synthesis. The selectivity of this inhibitor makes it useful in treating diabetes mellitus type 2.

• Brand: Biosynth

Chemical properties

• Molecular weight: 204.18 g/mol
• Formula: C₁₀H₈N₂O₃
• Purity: Min. 95%
• InChI: InChI=1S/C10H8N2O3/c1-15-10(14)8(13)7-5-12-9-6(7)3-2-4-11-9/h2-5H,1H3,(H,11,12)
• InChI key: InChIKey=LXGPNHJNIRDJER-UHFFFAOYSA-N
• SMILES: COC(=O)C(=O)c1c[nH]c2ncccc12