Product Information
- 7-Methoxy-1,2-dimethyl-9H-pyrido[3,4-b]indolium
2-Methyl harmine is a plant-derived compound that reversibly inhibits the enzyme L-DOPA decarboxylase, which is involved in the synthesis of dopamine. This inhibition causes an increase in dopamine levels, which may be beneficial for Parkinson's disease patients. The binding of 2-methyl harmine to the substrate site on L-DOPA decarboxylase and its allosteric binding to the cofactor site are competitive and reversible. The thermodynamic effects of 2-methyl harmine on this enzyme are related to its ability to inhibit it with a potency that is greater than that of toloxatone and other analogs.