1-Methyl-nicotinamide methosulphate
CAS: 58971-09-8
Ref. 3D-FM25889
| 1g | To inquire | ||
| 2g | To inquire | ||
| 5g | To inquire | ||
| 10g | To inquire | ||
| 500mg | To inquire |
Product Information
- 3-(Aminocarbonyl)-1-methylpyridinium
1-Methyl-nicotinamide methosulphate (1MNMS) is a drug that can be used in the treatment of nicotine addiction. It is an iminium chloride that binds to nicotine, forming nicotinamide and 1-methylpyridinium ion. This binding prevents the metabolism of nicotine by the liver, which leads to a decrease in the production of cotinine and other metabolites. The affinity of 1MNMS for nicotine is approximately 2 times higher than for nicotinamide, and it has been shown that this drug has a metabolic transformation mediated by CYP2A6, CYP2B6, CYP2C8 and CYP3A4 enzymes. In addition, 1MNMS can react with oxygen molecules to form an aldehyde intermediate or an aldehyde oxidase (ALOX) metabolite.
Chemical properties
Technical inquiry about: 3D-FM25889 1-Methyl-nicotinamide methosulphate
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