5,10-Methylene-5,6,7,8-tetrahydrofolic acid - mixture of diastereomers

CAS: 3432-99-3

Ref. 3D-FM31365

Product Information

• Name: 5,10-Methylene-5,6,7,8-tetrahydrofolic acid - mixture of diastereomers
• Synonyms: Folitixorin, (+)-5,10-Methylene-5,6,7,8-tetrahydrofolic acid, (2s)-2-(4-(3-Amino-1-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzamido)pentanedioic acid, 5,10-Methylene-(6RS)-tetrahydrofolic acid, 5,10-Methylenetetrafolate, 5,10-Methylenetetrahydrofolic acid, <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, Anx-510, Folic acid, tetrahydro-N⁵,N¹⁰-methylene-, Glutamic acid, N-[p-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, <span class="text-smallcaps">L</span>-, Imidazo[1,5-f]pteridine, <span class="text-smallcaps">L</span>-glutamic acid deriv., L-glutamic acid, N-[4-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, N-[4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid, N-[4-(3-amino-1-hydroxy-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid, N-{4-[(6aR)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid, N⁵,N¹⁰-Methylene-5,6,7,8-tetrahydrofolic acid, N⁵,N¹⁰-Methylenetetrahydrofolic acid, N⁵,N¹⁰-Methylenetetrahydropteroylglutamic acid

Description

5,10-Methylene-5,6,7,8-tetrahydrofolic acid is a molecule that is found in cells. It is an essential cofactor for many biological processes. The folate form of 5,10-methylene-5,6,7,8-tetrahydrofolic acid (5MTHF) can be synthesized by the enzyme methylenetetrahydrofolate reductase. This enzyme uses N5,N10-methenyltetrahydrofolate as a substrate and converts it to 5MTHF. The enzyme activity of methylenetetrahydrofolate reductase can be inhibited by methotrexate. In this case 5MTHF will not be produced and the body's supply of folate will decrease. The structural analysis of 5MTHF has been performed using titration calorimetry and x-ray crystallography.

• Brand: Biosynth

Chemical properties

• Molecular weight: 457.44 g/mol
• Formula: C₂₀H₂₃N₇O₆
• Purity: 80%Min
• Color/Form: Powder
• InChI: InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1
• InChI key: InChIKey=QYNUQALWYRSVHF-ABLWVSNPSA-N
• SMILES: Nc1nc2c(c(=O)[nH]1)N1CN(c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)CC1CN2