4'-(Methylsulfonyl)acetophenone

CAS: 10297-73-1

Ref. 3D-FM35479

Product Information

• Name: 4'-(Methylsulfonyl)acetophenone
• Synonyms: 1-(4-Methanesulfonylphenyl)ethan-1-one, 1-(4-Methylsulfonylphenyl)ethanone, 1-[4-(Methylsulfonyl)Phenyl]Ethanone, 1-[4-(Methylsulfonyl)phenyl]ethan-1-one, 4-(Methanesulfonyl)acetophenone, 4-(Methylsulfonyl)propiophenone, 4-Methylsulphonyl Acetophenone, 4-Methylsulphonylacetophenone, 4′-(Methylsulfonyl)acetophenone, Acetophenone, 4′-(methylsulfonyl)-, Ethanone, 1-[4-(methylsulfonyl)phenyl]-, NSC 403928, p-Acetylphenyl methyl sulfone, p-Methylsulfonylacetophenone

Description

4'-(Methylsulfonyl)acetophenone is a quinoline derivative and an inhibitor of the COX-2 enzyme. It has significant anti-inflammatory activity, and has been shown to inhibit inflammation in mammals. 4'-(Methylsulfonyl)acetophenone also inhibits the production of hormones in mammalian cells, including testosterone, progesterone, and estrogens. The molecular modeling study on this molecule showed that it has a pharmacophore with a cox-2 inhibitory region and an aromatic ring. The study also showed that 4'-(Methylsulfonyl)acetophenone inhibited bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication.

• Brand: Biosynth

Chemical properties

• Molecular weight: 198.24 g/mol
• Formula: C₉H₁₀O₃S
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C9H10O3S/c1-7(10)8-3-5-9(6-4-8)13(2,11)12/h3-6H,1-2H3
• InChI key: InChIKey=KAVZYDHKJNABPC-UHFFFAOYSA-N
• SMILES: CC(=O)c1ccc(S(C)(=O)=O)cc1