6-Maleimidocaproic acid N-hydroxysuccinimide ester

CAS: 55750-63-5

Ref. 3D-FM48296

Product Information

• Name: 6-Maleimidocaproic acid N-hydroxysuccinimide ester
• Synonyms: N-Succinimidyl 6-maleimidocaproateEMCS, 1-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-1H-pyrrole-2,5-dione, 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester, 1H-Pyrrole-2,5-dione, 1-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-, 2,5-Dioxopyrrolidin-1-yl 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate, 6-Maleimidohexanoic acid N-hydroxysuccinimide ester, 6-Maleimidohexanoic acid N-succinimidyl ester, N-(6-Maleimide caproyloxy) succinimide, N-(6-Maleimideocaproyloxy)succinimide, N-(6-Maleimidocaproyloxy)succinimide, N-(epsilon-Maleimidocaproyloxy)succinimide, N-(ε-Maleimidocaproyloxy)succinimide, N-Succinimidyl 6-maleimidohexanoate, ε-Maleimidocaproic acid N-hydroxysuccinimide ester
• CAS: 55750-63-5

Description

6-Maleimidocaproic acid N-hydroxysuccinimide ester (6MCA-NHS) is a fluorescent probe that reacts with the hydroxyl group of fatty acids in human serum and other biological samples. 6MCA-NHS binds to the carboxylic acid group at the end of a fatty acid molecule, forming a covalent bond. This process generates light emission that can be detected by a fluorescence probe to measure changes in pH or other chemical properties within the solution. 6MCA-NHS has been used as a tumor treatment, where laser ablation is used to break up tumor cells and release 6MCA-NHS into the cytoplasm. The drug can then bind to DNA molecules and inhibit protein synthesis, which results in cell death.

• Brand: Biosynth

Chemical properties

• Molecular weight: 308.29 g/mol
• Formula: C₁₄H₁₆N₂O₆
• Purity: Min. 95%
• Color/Form: White Off-White Powder
• InChI: InChI=1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2
• InChI key: InChIKey=VLARLSIGSPVYHX-UHFFFAOYSA-N
• SMILES: O=C(CCCCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O