1-Methyl-1H-pyrazole-4-sulfonyl chloride

CAS: 288148-34-5

Ref. 3D-FM59463

Product Information

• Name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride
• Synonyms: 1-methyl-1H-pyrazole-4-sulfonyl chloride, 1H-Pyrazole-4-Sulfonylchloride, 1-Methyl-, 4-Chlorosulfonylpyrazole
• CAS: 288148-34-5

Description

1-Methyl-1H-pyrazole-4-sulfonyl chloride is selective for the b-Raf protein, inhibiting it by binding to its active site on the molecule. This binding prevents ATP from binding and initiates the conformational change necessary for Raf activation. 1-Methyl-1H-pyrazole-4-sulfonyl chloride has been shown to inhibit cellular proliferation in a number of tissues including lung, colon, and prostate. The mechanism of action is hypothesized to be due to inhibition of b-Raf. The selectivity of 1MPYSC has been rationalized by profiling analyses that have identified a number of mutant molecules with different binding affinities for wild type and mutant b-Raf proteins.

• Brand: Biosynth

Chemical properties

• Molecular weight: 180.61 g/mol
• Formula: C₄H₅ClN₂O₂S
• Purity: Min. 95%
• InChI: InChI=1S/C4H5ClN2O2S/c1-7-3-4(2-6-7)10(5,8)9/h2-3H,1H3
• InChI key: InChIKey=RDAVKKQKMLINOH-UHFFFAOYSA-N
• SMILES: Cn1cc(S(=O)(=O)Cl)cn1