Madecassic acid

CAS: 18449-41-7

Ref. 3D-FM73960

Product Information

• Name: Madecassic acid
• Synonyms: 6beta-Hydroxyasiatic acid, (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-Trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid, (2Alpha,3Beta,5Xi,6Beta,9Xi)-2,3,6,23-Tetrahydroxyurs-12-En-28-Oic Acid, (2Alpha,3Beta,6Beta)-2,3,6,23-Tetrahydroxyurs-12-En-28-Oic Acid, (2α,3β,4α,6β)-2,3,6,23-Tetrahydroxyurs-12-en-28-oic acid, 2,3,6,23-Tetrahydroxyurs-12-En-28-Oic Acid, 2α,3β,6β,23-Tetrahydroxy-urs-12-en-28-oic acid, 6β-Hydroxyasiatic acid, Brahmic acid, Cid 12073158, Nsc 88135, Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2alpha,3beta,4alpha,6beta)-, Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,4α,6β)-, Urs-12-en-28-oic acid, 2α,3β,6β,23-tetrahydroxy-
• CAS: 18449-41-7

Description

Madecassic acid (MA) is a natural compound that has been shown to inhibit cyclic nucleotide phosphodiesterases. These enzymes are responsible for the breakdown of cyclic nucleotides, which are important for cell signaling and regulation. Madecassic acid also inhibits the production of pro-inflammatory cytokine IL-10 in vitro and may be a potential treatment for inflammatory disorders such as asthma and arthritis. MA is structurally related to other inhibitors of cyclic nucleotide phosphodiesterases, such as quinolones, cephalosporins, and macrolides. The inhibition of these enzymes by MA may be responsible for its antimicrobial activity against both Gram-positive and Gram-negative bacteria.

• Brand: Biosynth

Chemical properties

• Molecular weight: 504.7 g/mol
• Formula: C₃₀H₄₈O₆
• Purity: Min. 95%