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18-Nor-17b-estradiol
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18-Nor-17b-estradiol

CAS: 15093-14-8

Ref. 3D-FN26421

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Estimated delivery in United States, on Tuesday 10 Dec 2024

Product Information

Name:
18-Nor-17b-estradiol
Synonyms:
  • (17b)-Gona-1,3,5(10)-triene-3,17-diol18,19-Dinorandrosta-1,3,5(10)-triene-3,17b-diolGona-1,3,5(10)-triene-3,17b-diol
Description:

18-Nor-17b-estradiol is a synthetic estrogen that has been used in the treatment of breast cancer. It can be synthesized in two steps from 17β-estradiol, which is the major endogenous estrogen. 18-Nor-17b-estradiol is a prodrug, which undergoes hydration and oxidation to form estrone. This drug has high affinity for both estrogen receptors alpha and beta, and it is an agonist of the progesterone receptor. It binds to the DNA response element with sequence 5'-TGACGTCA-3' (site II) and enhances transcription by binding to its receptor at the nucleus. 18-Nor-17b-estradiol can also be acetylated at position C18 by microbial transformation or acetylation enzymes, which may lead to activation or inactivation of this compound. 18-Nor-17b-estradiol analogs are also available. These analogs have different conformational

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
258.36 g/mol
Formula:
C17H22O2
Purity:
Min. 95%
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Merck:
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
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LQ:

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