(R)-(-)-nipecotic acid

CAS: 25137-00-2

Ref. 3D-FN55407

Product Information

• Name: (R)-(-)-nipecotic acid
• Synonyms: (R)-()-3-Piperidinecarboxylic acid, (-)-Nipecotic acid, (3R)-3-Piperidinecarboxylic acid, (3R)-Piperidine-3-carboxylic acid, (3R)-piperidinium-3-carboxylate, (3S)-piperidinium-3-carboxylate, (R)-3-Piperidinecarboxylic acid, 3-Piperidinecarboxylic acid, (3R)-, 3-Piperidinecarboxylic acid, (R)-, <span class="text-smallcaps">L</span>-(-)-Nipecotic acid, D-Piperidine-3-carboxylic acid, Nipecotic acid, (R)-(-)-, R-(-)-Piperidine-3-carboxylic acid

Description

(R)-(-)-Nipecotic acid is a non-competitive inhibitor of gamma-aminobutyric acid (GABA) uptake. It is also a cholinergic antagonist and an inhibitor of GABA uptake in vitro. Nipecotic acid has been shown to have anticonvulsant effects in animal models and to be effective in the treatment of alcohol withdrawal syndrome. Nipecotic acid has been shown to protect against seizures induced by potassium chloride, pentylenetetrazole, or glutamate in rat brain slices as well as by electroconvulsive shock. It also prevents convulsions induced by pentylenetetrazole or kainic acid when applied locally on the cerebral cortex. The mechanism for this effect may be due to inhibition of GABA uptake by nipecotic acid or an increase in the release of GABA from nerve endings.

• Brand: Biosynth

Chemical properties

• Molecular weight: 129.16 g/mol
• Formula: C₆H₁₁NO₂
• Purity: Min. 95%
• InChI: InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
• InChI key: InChIKey=XJLSEXAGTJCILF-RXMQYKEDSA-N
• SMILES: O=C(O)[C@@H]1CCCNC1