n-(1-naphthyl)thiourea

CAS: 86-88-4

Ref. 3D-FN59007

Product Information

• Name: n-(1-naphthyl)thiourea
• Synonyms: 1-(1-Naphthyl)-2-thiourea, 1-(1-Naphthyl)thiourea, 1-(Naphthalen-1-yl)thiourea, 1-Naphthalen-1-Ylthiourea, 1-Naphthylthiourea, Alrato, Anturat, Bantu, Chemical 109, Dirax, Kripid, Krysid, N-1-Naphthalenylthiourea, N-1-Naphthylthiourea, NSC 3287, Naphthalen-1-ylthiourea, Naphtox, Rattrack, Smeesana, Thiourea, 1-naphthalenyl-, Thiourea, N-1-naphthalenyl-, U 5227, Urea, 1-(1-naphthyl)-2-thio-, Α-Naphthyl Thiourea, α-Naphthylthiocarbamide, α-Naphthylthiourea

Description

Naphthylthiourea is a drug that has been shown to have a specific antidote effect in experimental models of pulmonary bacterial sepsis. This drug inhibits the enzyme, dihydrofolate reductase, which is responsible for the synthesis of tetrahydrofolic acid and folinic acid. Naphthylthiourea also inhibits the bacterial strain’s ability to bind to host cells by inhibiting folate-dependent DNA synthesis. These effects are mediated through naphthylthiourea’s inhibition of purine biosynthesis and its ability to inhibit transcription of bacterial DNA gyrase and topoisomerase IV. The chronic oral exposure to naphthylthiourea leads to lung damage, which may be due to its chemiluminescence method.

• Brand: Biosynth

Chemical properties

• Molecular weight: 202.28 g/mol
• Formula: C₁₁H₁₀N₂S
• Purity: Min. 95%
• InChI: InChI=1S/C11H10N2S/c12-11(14)13-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H3,12,13,14)
• InChI key: InChIKey=PIVQQUNOTICCSA-UHFFFAOYSA-N
• SMILES: NC(=S)Nc1cccc2ccccc12