γ-Oxo-3-pyridinebutyric acid

CAS: 4192-31-8

Ref. 3D-FO26681

Product Information

• Name: γ-Oxo-3-pyridinebutyric acid
• Synonyms: γ-Oxo-3-pyridinebutanoic acid3-Succinoylpyridine4-(3-Pyridyl)-4-oxobutyric acid

Description

Gamma-oxo-3-pyridinebutyric acid (GOBA) is a non-protein amino acid that has been shown to be involved in the development of cancer. GOBA was found to be present in urine samples from patients with liver cancer and breast cancer, as well as in healthy individuals. GOBA is also present in rat liver microsomes and human liver, where it is converted into gamma-aminobutyric acid (GABA). This conversion may be due to GOBA's hydroxy group that can be oxidized by cytochrome P450 enzymes. The biological activity of GOBA appears to depend on its carboxyl group, which can form a complex with molybdenum. This complex inhibits the activity of the protein polymerase chain reaction, leading to a decrease in transcriptional regulation. In animal experiments, GOBA has been shown to inhibit tumor growth and induce cell cycle arrest by inhibiting the expression of cyclin D1 at the

• Brand: Biosynth

Chemical properties

• Molecular weight: 179.17 g/mol
• Formula: C₉H₉NO₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C9H9NO3/c11-8(3-4-9(12)13)7-2-1-5-10-6-7/h1-2,5-6H,3-4H2,(H,12,13)
• InChI key: InChIKey=JGSUNMCABQUBOY-UHFFFAOYSA-N
• SMILES: O=C(O)CCC(=O)c1cccnc1