Pradigastat
CAS: 956136-95-1
Ref. 3D-FP103386
| 1mg | Discontinued | ||
| 2mg | Discontinued | ||
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued |
Product Information
Name:
Pradigastat
Synonyms:
- Lcq 908Nxa
- trans-4-[4-[5-[[6-(Trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]cyclohexaneacetic acid
Description:
Pradigastat is a small molecule that inhibits the activity of diacylglycerol acyltransferase-2 (DGAT-2) and hepatic lipase. It is used to treat patients with high levels of low-density lipoprotein cholesterol (LDL-C). Pradigastat binds to the active site of DGAT-2 and blocks the transfer of fatty acids from diacylglycerol to triglycerides, which reduces the production of chylomicrons. This compound also inhibits hepatic lipase, which reduces the production and secretion of VLDLs. In addition, pradigastat has antimicrobial effects against bacteria such as Helicobacter pylori, which are known to cause gastric ulcers. Pradigastat also prevents viral replication by inhibiting human macrophages involved in lipid metabolism.
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
455.47 g/mol
Formula:
C25H24F3N3O2
Purity:
Min. 95%
InChI:
InChI=1S/C25H24F3N3O2/c26-25(27,28)23-12-10-21(15-30-23)31-20-9-11-22(29-14-20)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-24(32)33/h5-12,14-17,31H,1-4,13H2,(H,32,33)
InChI key:
InChIKey=GXALXAKNHIROPE-UHFFFAOYSA-N
SMILES:
O=C(O)CC1CCC(c2ccc(-c3ccc(Nc4ccc(C(F)(F)F)nc4)cn3)cc2)CC1
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