Product Information
- Arry-614
Pexmetinib is a tyrosine kinase inhibitor that binds to the ATP-binding pocket of the target enzyme. This binding inhibits the activity of enzymes, such as mitogen-activated protein kinases (MAPKs), which regulate cellular proliferation, differentiation, and apoptosis. Pexmetinib has shown efficacy in clinical studies for the treatment of tumor xenografts and inflammatory diseases. It has been shown to be effective in inhibiting growth factor signaling and cell proliferation in cancer cells. Pexmetinib also inhibits p38 MAPK signaling pathways that are involved in inflammation, autoimmune diseases, and hematopoietic malignancies. The effective dose of pexmetinib is 4 mg/kg per day given orally or intravenously.
Chemical properties
Technical inquiry about: 3D-FP103620 Pexmetinib
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