Polyphemusin II-Derived Peptide
CAS: 229030-20-0
Ref. 3D-FP109318
| 1mg | 1,243.00 € | ||
| 2mg | 2,164.00 € | ||
| 100µg | 273.00 € | ||
| 250µg | 460.00 € | ||
| 500µg | 763.00 € |
Product Information
- H-Arg-Arg-2-Nal-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH H-RR(2-Nal)CYRK(dK)PYR(Cit)CR-OH
- 68:PN: WO2008075370 SEQID: 69 claimed protein
- 69: PN: WO2008075369 SEQID: 69claimed protein
- T 140
- T 140 (peptide)
Polyphemusin II-derived peptide H-Arg-Arg-2-Nal-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit (PIIH) is a cyclic polypeptide with a disulfide bond. PIIH binds to the alpha4beta1 integrin receptor, which is involved in the adhesion of leukocytes to endothelial cells and the migration of monocytes and lymphocytes. PIIH has been shown to be a potent inhibitor of chemokine binding to cxcr4, an important regulator of inflammatory response in mouse tumor models. PIIH also inhibits hiv infection as it inhibits the release of virus from infected cells. This pharmacological effect is mediated by its ability to bind HIV gp120 and block gp120 binding to CD4 receptors on target cells.
Chemical properties
Technical inquiry about: 3D-FP109318 Polyphemusin II-Derived Peptide
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