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3-(1H-Pyrazol-3-yl)pyridine
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3-(1H-Pyrazol-3-yl)pyridine

CAS: 45887-08-9

Ref. 3D-FP122768

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Estimated delivery in United States, on Thursday 2 Jan 2025

Product Information

Name:
3-(1H-Pyrazol-3-yl)pyridine
Synonyms:
  • pyridine
  • 3-(1H-pyrazol-3-yl)-
  • pyridine, 3-(1H-pyrazol-3-yl)-
Description:

3-(1H-Pyrazol-3-yl)pyridine (PPY) is a potent and selective inhibitor of cyclooxygenase-2 (COX-2). PPY has been shown to inhibit COX-2 activity with an IC50 value of 0.4 μM. PPY does not inhibit COX-1, which is responsible for the production of prostaglandins that maintain the normal function of the stomach and intestine. PPY also has a low safety profile, with no significant effects on the heart or kidneys in animal studies. The compound is being developed as a potential treatment for inflammatory diseases such as rheumatoid arthritis. The drug was originally discovered by screening chemical libraries for compounds that could inhibit COX-2 activity. Molecular docking studies have shown that PPY binds to the active site of COX-2, preventing access to substrates and thereby inhibiting catalytic activity.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
145.16 g/mol
Formula:
C8H7N3
Purity:
Min. 95%
InChI:
InChI=1S/C8H7N3/c1-2-7(6-9-4-1)8-3-5-10-11-8/h1-6H,(H,10,11)
InChI key:
InChIKey=JJLMOUMOJSUSSX-UHFFFAOYSA-N
SMILES:
c1cncc(-c2ccn[nH]2)c1
MDL:
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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