Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione

CAS: 37538-68-4

Ref. 3D-FP153920

Product Information

• Name: Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
• Synonyms: 1H,3H-Pyrido[3,2-d]pyrimidine-2,4-dione, 2,4-Dihydroxypyrido[3,2-d]pyrimidine, 1H,2H,3H,4H-Pyrido[3,2-d]pyrimidine-2,4-dione, Pyrido[3,2-d]pyrimidine-2,4-diol

Description

Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione is a purine derivative that blocks the activity of c1-6 alkyl phosphodiesterases. It has been shown to have clinical efficacy in the treatment of muscle wasting and asthma. In cancer cells, pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione inhibits the tyrosine kinase activity of enzymes called protein kinase C (PKC) and mitogen activated protein kinase (MAPK). This inhibition prevents cell proliferation and induces apoptosis. Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione also inhibits cyclooxygenase 2 (COX2) and lipoxygenase activities in the cytoplasmic membrane. This results in decreased production of prostaglandins and leuk

• Brand: Biosynth

Chemical properties

• Molecular weight: 163.13 g/mol
• Formula: C₇H₅N₃O₂
• Purity: Min. 95%
• InChI: InChI=1S/C7H5N3O2/c11-6-5-4(2-1-3-8-5)9-7(12)10-6/h1-3H,(H2,9,10,11,12)
• InChI key: InChIKey=BJLUORNGPCXNHM-UHFFFAOYSA-N
• SMILES: O=c1[nH]c(=O)c2ncccc2[nH]1