Plevitrexed

CAS: 153537-73-6

Ref. 3D-FP27101

Product Information

• Name: Plevitrexed
• Synonyms: (a-S)-a-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid, (2S)-2-((4-(((2,7-Dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-ynyl)amino)-2-fluorobenzoyl)amino)-4-(1H-tetrazol-5-yl)butanoic acid, (2S)-2-[(4-{[(2,7-dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}-2-fluorobenzoyl)amino]-4-(2H-tetrazol-5-yl)butanoic acid, (aS)-a-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid, 1H-Tetrazole-5-butanoic acid, α-[[4-[[(1,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-, (S)-, 1H-Tetrazole-5-butanoic acid, α-[[4-[[(1,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-, (αS)-, Bgc 9331, Fluorobenzamido)-4-(1H-Tetrazol-5-Yl)Butyric Acid, Nsc 696259, Vamidex, Zd 9331

Description

Plevitrexed is a prodrug that is converted in the body to its active form, pemetrexed. Plevitrexed has been shown to inhibit the enzyme thymidylate synthase and has been used for the treatment of colorectal cancer. It is also effective against metastatic colorectal cancer, as well as other types of solid tumours. The target enzymes for plevitrexed are found at physiological levels and include trifluoroacetic acid synthetase, which helps to regulate cellular thymidylate levels. Plevitrexed inhibits both DNA-dependent RNA polymerase and protein synthesis in cells with minimal toxicity. This drug also has an ester linkages, which may be responsible for its stability in biological systems.

• Brand: Biosynth

Chemical properties

• Molecular weight: 532.53 g/mol
• Formula: C₂₆H₂₅FN₈O₄
• Purity: Min. 95%
• InChI: InChI=1S/CH4/h1H4
• InChI key: InChIKey=VNWKTOKETHGBQD-UHFFFAOYSA-N
• SMILES: C#CCN(Cc1cc2c(=O)[nH]c(C)nc2cc1C)c1ccc(C(=O)N[C@@H](CCc2nn[nH]n2)C(=O)O)c(F)c1