Propargyl methanesulfonate ester

CAS: 16156-58-4

Ref. 3D-FP27194

Product Information

• Name: Propargyl methanesulfonate ester
• Synonyms: Methanesulfonic acid prop-2-ynyl esterNSC 203079, 2-Propyn-1-ol,methanesulfonate, 2-Propynyl Methanesulfonate, Methanesulfonic Acid Prop-2-Ynyl Ester, Propargyl Mesylate, Propargyl Methylsulfonate, Prop-2-Yn-1-Yl Methanesulfonate
• CAS: 16156-58-4

Description

Propargyl methanesulfonate ester is an organic compound that is used as a cross-coupling reagent in the synthesis of chiral mesylates. It is prepared by treatment of propargyl alcohol with methanesulfonyl chloride and sodium hydroxide in an organic solvent. The product is purified by removal of the solvent, followed by crystallization or distillation. The mesylate group reacts with an amine to give a secondary amine, which can be converted to a carbamate or mediated reaction product. This process can also generate genotoxic impurities, such as dioxane and 1,4-dioxane, which are removed by transfer to an inert solvent.

• Brand: Biosynth

Chemical properties

• Molecular weight: 134.15 g/mol
• Formula: C₄H₆O₃S
• Purity: Min. 95%
• Color/Form: Clear Liquid
• InChI: InChI=1S/CH4/h1H4
• InChI key: InChIKey=VNWKTOKETHGBQD-UHFFFAOYSA-N
• SMILES: C#CCOS(C)(=O)=O