Propyzamide

CAS: 23950-58-5

Ref. 3D-FP27240

Product Information

• Name: Propyzamide
• Synonyms: 3,5-Dichloro-N-(1,1-dimethyl-2-propyn-1-yl)benzamide3,5-Dichloro-N-(1,1-dimethylpropynyl)benzamideKerb, 3,5-Dichlor-N-(1,1-dimethylprop-2-inyl)benzamid, 3,5-Dichloro-N-(1,1-dimethyl-2-propyn-1-yl)benzamide, 3,5-Dichloro-N-(1,1-dimethyl-2-propynyl)benzamide, 3,5-Dichloro-N-(1,1-dimethylprop-2-ynyl)aminocarbonylbenzene, 3,5-Dichloro-N-(1,1-dimethylprop-2-ynyl)benzamide, 3,5-dichloro-N-(1,1-dimethylpropynyl) benzamide, 3,5-dichloro-N-(2-methylbut-3-yn-2-yl)benzamide, 3,5-dicloro-N-(1,1-dimetilprop-2-inil)benzamida, Benzamide, 3,5-dichloro-N-(1,1-dimethyl-2-propyn-1-yl)-, Benzamide, 3,5-dichloro-N-(1,1-dimethyl-2-propynyl)-, Kerb, Kerb 50W, Kerb Flo, Kerb Flo 500, N-(1,1-Dimethylpropynyl)-3,5-dichlorobenzamide, Pronamide, Propyzamid, Rh 315

Description

Propyzamide is an anti-diabetic drug that is used to treat hypertension and congestive heart failure. Propyzamide inhibits the activity of the enzyme picolinic acid carboxylase, which is involved in the synthesis of nicotinic acid (niacin) from tryptophan. Propyzamide binds to a region of the enzyme that binds picolinic acid and competes with it for binding sites on the enzyme. This inhibition prevents nicotinic acid from being synthesized and lowers blood glucose levels. Propyzamide also has been shown to bind to nuclear DNA and human kidney bean, although its mechanism of action is not well understood.

The following are some common side effects associated with propyzamide: dizziness, drowsiness, dry mouth, nausea, vomiting, abdominal pain, diarrhea, constipation, headache, blurred vision or dry eyes.

• Brand: Biosynth

Chemical properties

• Molecular weight: 256.13 g/mol
• Formula: C₁₂H₁₁Cl₂NO
• Purity: Min. 95%
• InChI: InChI=1S/CH4/h1H4
• InChI key: InChIKey=VNWKTOKETHGBQD-UHFFFAOYSA-N
• SMILES: C#CC(C)(C)NC(=O)c1cc(Cl)cc(Cl)c1