Purmorphamine

CAS: 483367-10-8

Ref. 3D-FP27264

Product Information

• Name: Purmorphamine
• Synonyms: 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
• CAS: 483367-10-8

Description

Purmorphamine is a cell factor that belongs to the group of morphogens. It is structurally related to dopamine and has been shown to be effective in the treatment of Parkinson's disease. Purmorphamine is involved in the regulation of neuronal survival, differentiation, proliferation, and axon guidance. Purmorphamine binds to a receptor on neurons called the cholinergic receptor, which stimulates a G-protein linked signal transduction pathway. This leads to an increase in intracellular calcium levels and activation of protein kinase C. Purmorphamine also has anti-inflammatory effects and can inhibit leukemia inhibitory factor (LIF). It has been shown to be effective against LPS-induced inflammatory responses by inhibiting protein synthesis. Purmorphamine also inhibits cancer cells through its ability to stimulate growth factor-β1 (GF-β1) gene expression.

• Brand: Biosynth

Chemical properties

• Molecular weight: 520.63 g/mol
• Formula: C₃₁H₃₂N₆O₂
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
• InChI key: InChIKey=FYBHCRQFSFYWPY-UHFFFAOYSA-N
• SMILES: c1ccc2c(Oc3nc(Nc4ccc(N5CCOCC5)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1