(Z)-Desbutyl lumefantrine
CAS: 355841-11-1
Ref. 3D-FPA84111
| 1mg | 77.00 € | ||
| 2mg | 108.00 € | ||
| 5mg | 172.00 € | ||
| 10mg | 271.00 € | ||
| 25mg | 400.00 € |
Product Information
- (9Z)-α-[(Butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-9H-fluorene-4-methanol
- Desbutyl-benflumetol
- Desbutyllumefantrine
(Z)-Desbutyl lumefantrine (DBL) is a drug used for the treatment and prevention of malaria. The drug is a prodrug that is converted to lumefantrine in vivo. DBL has significant interactions with other drugs, such as trifluoroacetic acid, which may lead to toxic effects or therapeutic failure. DBL should not be taken by nonpregnant women or women who are pregnant, as it can cause birth defects in the fetus. Pharmacokinetics of DBL were studied in healthy adult subjects and found to have linear pharmacokinetic properties in the concentration-time curve. It had a mean elimination half-life of 5 hours, an oral bioavailability of 98%, and low systemic clearance (0.2 L/h).
Chemical properties
Technical inquiry about: 3D-FPA84111 (Z)-Desbutyl lumefantrine
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