D-Serine methyl ester HCl

CAS: 5874-57-7

Ref. 3D-FS11274

Product Information

• Name: D-Serine methyl ester HCl
• Synonyms: (2E)-2-cyano-3-(1-phenyl-3-thiophen-2-yl-1H-pyrazol-4-yl)prop-2-enamide, (2R)-3-Hydroxy-l-methoxy-l-oxopropan-2-aminium chloride, (R)-2-Amino-3-hydroxypropionic acid methyl ester hydrochloride, (R)-Methyl 2-amino-3-hydroxypropanoate hydrochloride, 4-bromo-N-{1-[3-(4-bromophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methylbenzenesulfonamide, <span class="text-smallcaps">D</span>-Serine, methyl ester, hydrochloride, <span class="text-smallcaps">D</span>-Serine, methyl ester, hydrochloride (1:1), D-Ser-OMe.HCl, D-serine methyl ester hcl, H-D-Ser-OMe*HCl, H-D-Ser-OMe・HCl, Methyl <span class="text-smallcaps">D</span>-serinate hydrochloride, Serine, methyl ester, hydrochloride, <span class="text-smallcaps">D</span>-, Serine, methyl ester, hydrochloride, D-, Methyl D-serinate hydrochloride, D-Serine, methyl ester, hydrochloride, D-Serine, methyl ester, hydrochloride (1:1)

Description

D-Serine methyl ester HCl is an amide that is used as an intermediate in the preparation of lacosamide, an antiepileptic drug. It is prepared by methylation of D-serine with methanol. This reaction can be carried out under neutral or basic conditions and produces the same product. The synthetic route starts with the reaction of thionyl chloride with l-glutamic acid to afford the corresponding acid chloride, which can then be reacted with methanol to give a mixture of stereoisomers. The methyl esters hydrochloride salt is also available commercially, although it is less expensive to synthesize this compound from recycled starting materials. In mammalian cells, D-serine methyl ester HCl inhibits actin filament assembly by binding to actin monomers and inhibiting their polymerization into filaments.

• Brand: Biosynth

Chemical properties

• Molecular weight: 155.58 g/mol
• Formula: C₄H₉NO₃·HCl
• Purity: Min. 95%
• Color/Form: White To Off-White Solid