2-Thiothymine

CAS: 636-26-0

Ref. 3D-FT11851

Product Information

• Name: 2-Thiothymine
• Synonyms: 5-Methyl-2-thiouracil4-Hydroxy-2-mercapto-5-methylpyrimidine, 2,3-Dihydro-5-methyl-2-thioxo-4(1H)-pyrimidinone, 4(1H)-Pyrimidinone, 2,3-dihydro-5-methyl-2-thioxo-, 4-Hydroxy-2-mercapto-5-methylpyrimidine, 4-Hydroxy-5-methyl-2-mercaptopyrimidine, 4-Hydroxy-5-methylpyrimidine-2-thione, 5-Methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, NSC 314272, NSC 9377, Thiothymine, Thymine, 2-thio-
• CAS: 636-26-0

Description

2-Thiothymine is a nucleotide that can be synthesized by the polymerase chain reaction. It is used as a probe for determining the sequence of DNA duplexes. 2-Thiothymine binds to dna and forms hydrogen bonds with the nitrogen atoms in dna bases, which prevents them from being able to bind with other dna bases, thereby disrupting the binding of dna strands. This leads to chain reactions that result in high temperatures and could cause damage to the cells. 2-Thiothymine has been shown to be toxic to both bacteria and human cells. It was found to inhibit HIV infection by binding to viral RNA and preventing it from being translated into protein, leading to cell death.

• Brand: Biosynth

Chemical properties

• Molecular weight: 142.18 g/mol
• Formula: C₅H₆N₂OS
• Purity: Min. 95%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C5H6N2OS/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
• InChI key: InChIKey=ZLAQATDNGLKIEV-UHFFFAOYSA-N
• SMILES: Cc1c[nH]c(=S)[nH]c1=O