3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole

CAS: 65347-55-9

Ref. 3D-FT147718

Product Information

• Name: 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole
• Synonyms: 1,2,3,6-Tetrahydro-4-(3-indolyl)pyridine, 1H-Indole, 3-(1,2,3,6-tetrahydro-4-pyridinyl)-, 3-(1,2,3,6-Tetrahydro-4-pyridinyl)-1H-indole, 3-(1,2,3,6-Tetrahydro-4-pyridyl)-1H-indole, 3-(1,2,3,6-Tetrahydropyridin-4-yl)indole, 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-ol, 4-(Indol-3-yl)-1,2,3,6-tetrahydropyridine, Ru 24441

Description

3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole (THP) is an indole alkaloid that binds to the 5-HT1A receptor. THP has been shown to be a potent inhibitor of serotonin uptake in rat brain synaptosomes and is a more potent inhibitor of serotonin uptake than other indole alkaloids such as tryptamine and 5-methoxytryptamine. THP also blocks the effects of amphetamine on central reward pathways in rats and has antidepressant properties similar to drugs like fluoxetine. 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole is addictive and can cause depression when administered repeatedly.

• Brand: Biosynth

Chemical properties

• Molecular weight: 198.26 g/mol
• Formula: C₁₃H₁₄N₂
• Purity: Min. 95%
• InChI: InChI=1S/C13H14N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-5,9,14-15H,6-8H2
• InChI key: InChIKey=CIRSPTXGPFAXRE-UHFFFAOYSA-N
• SMILES: C1=C(c2c[nH]c3ccccc23)CCNC1