Tiglyl glycine

CAS: 35842-45-6

Ref. 3D-FT28274

Product Information

• Name: Tiglyl glycine
• Synonyms: N-[(2E)-2-Methyl-1-oxo-2-buten-1-yl]glycine, Glycine, N-(2-methyl-1-oxo-2-butenyl)-, (E)-, Glycine, N-[(2E)-2-methyl-1-oxo-2-buten-1-yl]-, Glycine, N-[(2E)-2-methyl-1-oxo-2-butenyl]-, N-Tigloylglycine, N-Tiglylglycine, N-[(2E)-2-methylbut-2-enoyl]glycine, Tiglylglycine

Description

Tiglyl glycine is a drug that belongs to the class of non-competitive inhibitors of the α1 subunit of mitochondrial polymerase. It has been shown to inhibit the synthesis of malonic acid, which is a metabolic product, and tiglic acid, which is an intermediate in energy metabolism. Tiglyl glycine has been shown to have therapeutic effects against infectious diseases and metabolic disorders such as methyl ethyl malonic aciduria, with symptoms including brain dysfunction, vomiting, and weight loss. Tiglyl glycine inhibits the production of methyl ethylmalonic acid from propionate in patients with this disorder. Tiglyl glycine also has been shown to be effective in reducing body mass index and human serum levels of malonic acid in obese patients.

• Brand: Biosynth

Chemical properties

• Molecular weight: 157.17 g/mol
• Formula: C₇H₁₁NO₃
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C7H11NO3/c1-3-5(2)7(11)8-4-6(9)10/h3H,4H2,1-2H3,(H,8,11)(H,9,10)/b5-3+
• InChI key: InChIKey=WRUSVQOKJIDBLP-HWKANZROSA-N
• SMILES: C/C=C(\C)C(=O)NCC(=O)O