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4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole
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4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole

CAS: 885618-33-7

Ref. 3D-FT52004

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Estimated delivery in United States, on Friday 17 Jan 2025

Product Information

Name:
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole
Synonyms:
  • 1H-Indazol-4-ylboronic acid pinacol ester
  • 1H-Indazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 1H-Indazole-4-boronic acid pinacol ester
  • 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol
  • 4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole
  • Indazole-4-boronic acid pinacol ester
Description:

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole is a phosphoinositide inhibitor that induces apoptosis in cancer cells. It targets the enzyme phosphatidylinositol 3-kinase (PI3K) and the downstream target of PI3K: phosphatidylinositol 3-phosphate (PI3P). The PI3P is a precursor for other lipids such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 4-phosphate (PIP). These lipids are involved in the regulation of cell proliferation and apoptosis. This compound has a significant inhibitory effect on cancer cell lines and inhibits cancer growth in an animal model.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
244.1 g/mol
Formula:
C13H17BN2O2
Purity:
Min. 95%
InChI:
InChI=1S/C13H17BN2O2/c1-12(2)13(3,4)18-14(17-12)10-6-5-7-11-9(10)8-15-16-11/h5-8H,1-4H3,(H,15,16)
InChI key:
InChIKey=YRPXZCWDXBNPBD-UHFFFAOYSA-N
SMILES:
CC1(C)OB(c2cccc3[nH]ncc23)OC1(C)C
MDL:
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EINECS:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
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Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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