4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole

CAS: 885618-33-7

Ref. 3D-FT52004

Product Information

• Name: 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole
• Synonyms: 1H-Indazol-4-ylboronic acid pinacol ester, 1H-Indazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1H-Indazole-4-boronic acid pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol, 4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole, Indazole-4-boronic acid pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole, 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole

Description

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole is a phosphoinositide inhibitor that induces apoptosis in cancer cells. It targets the enzyme phosphatidylinositol 3-kinase (PI3K) and the downstream target of PI3K: phosphatidylinositol 3-phosphate (PI3P). The PI3P is a precursor for other lipids such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 4-phosphate (PIP). These lipids are involved in the regulation of cell proliferation and apoptosis. This compound has a significant inhibitory effect on cancer cell lines and inhibits cancer growth in an animal model.

• Brand: Biosynth

Chemical properties

• Molecular weight: 244.1 g/mol
• Formula: C₁₃H₁₇BN₂O₂
• Purity: Min. 95%
• InChI: InChI=1S/C13H17BN2O2/c1-12(2)13(3,4)18-14(17-12)10-6-5-7-11-9(10)8-15-16-11/h5-8H,1-4H3,(H,15,16)
• InChI key: InChIKey=YRPXZCWDXBNPBD-UHFFFAOYSA-N
• SMILES: CC1(C)OB(c2cccc3[nH]ncc23)OC1(C)C