2-Thioxo-2,3-dihydroquinazolin-4(1h)-one

CAS: 13906-09-7

Ref. 3D-FT73243

Product Information

• Name: 2-Thioxo-2,3-dihydroquinazolin-4(1h)-one
• Synonyms: 2,3-Dihydro-2-thioxo-4(1H)-quinazolinone, 2,3-Dihydro-2-thioxoquinazolin-4(1H)-one, 2,4(1H,3H)-Quinazolinedione, 2-thio-, 2-Mercapto-3,4-dihydro-4-quinazolone, 2-Mercapto-3H-quinazolin-4-one, 2-Mercapto-4-quinazolinol, 2-Mercaptoquinazolin-4(1H)-one, 2-Mercaptoquinazolin-4-one, 2-Sulfanyl-1,4-dihydroquinazolin-4-one, 2-Sulfanyl-3,4-dihydroquinazolin-4-one, 2-Sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one, 2-Sulfanylidene-1H-quinazolin-4-one, 2-Sulfanylquinazolin-4-ol, 2-Thio-2,4(1H,3H)-quinazolinedione, 2-Thio-4-oxo-1,2,3,4-tetrahydroquinazoline, 2-Thioxo-2,3-dihydro-1H-quinazolin-4-one, 2-Thioxo-4-quinazolinone, 2-thioxo-2,3-dihydroquinazolin-4(1H)-one, 4(1H)-Quinazolinone, 2,3-dihydro-2-thioxo-

Description

2-Thioxo-2,3-dihydroquinazolin-4(1h)-one is an inhibitor of carbonic anhydrase. It has been shown to have a strong inhibitory effect on the enzyme's activity in vitro, with the IC50 value being around 0.5 mM. The compound was synthesised by reacting acetyl chloride and 4-chloro-3,5-dimethoxybenzaldehyde. This compound is stable in aqueous solution and can be used to inhibit carbonic anhydrase in analytical chemistry, cell culture, and human serum. 2-Thioxo-2,3-dihydroquinazolin-4(1h)-one has also been shown to be efficient for the determination of carbonic acid using vibrational spectroscopy.

• Brand: Biosynth

Chemical properties

• Molecular weight: 178.21 g/mol
• Formula: C₈H₆N₂OS
• Purity: Min. 95%
• InChI: InChI=1S/C8H6N2OS/c11-7-5-3-1-2-4-6(5)9-8(12)10-7/h1-4H,(H2,9,10,11,12)
• InChI key: InChIKey=PUPFOFVEHDNUJU-UHFFFAOYSA-N
• SMILES: O=c1[nH]c(=S)[nH]c2ccccc12