1-(2'-Tetrahydrothienyl)-5 Fluorouracil-1-'1'-Dioxide
CAS: 81486-02-4
Ref. 3D-FT93440
| Undefined size | Discontinued |
Product Information
Name:
1-(2'-Tetrahydrothienyl)-5 Fluorouracil-1-'1'-Dioxide
Synonyms:
- 2,4(1H,3H)-pyrimidinedione, 5-fluoro-1-(tetrahydro-1,1-dioxido-2-thienyl)-
Description:
1-(2'-Tetrahydrothienyl)-5 Fluorouracil-1-'1'-Dioxide (THTF) is an anti-cancer drug that is structurally related to 5-fluorouracil. It has been shown to be more resistant to oxidation and can be used in the treatment of skin cancer, cancer, and lymphocytic leukemia. THTF has been shown to inhibit the activity of oxidases, which are enzymes involved in the production of reactive oxygen species (ROS). This can lead to cell death by preventing DNA repair and oxidation of lipids. THTF has been shown to be effective against l1210 murine leukemia cells, but not human leukemia cells. The difference in sensitivity may be due to a different number of primers for PCR amplification or differences between the strains of mice used.
Notice:
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Brand:
Biosynth
Long term storage:
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Chemical properties
Molecular weight:
248.23 g/mol
Formula:
C8H9FN2O4S
Purity:
Min. 95%
InChI:
InChI=1S/C8H9FN2O4S/c9-5-4-11(8(13)10-7(5)12)6-2-1-3-16(6,14)15/h4,6H,1-3H2,(H,10,12,13)
InChI key:
InChIKey=YUPJZHWEUDXVQY-UHFFFAOYSA-N
SMILES:
O=c1[nH]c(=O)n(C2CCCS2(=O)=O)cc1F
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