Umbelliferone-3-carboxylic acid

CAS: 779-27-1

Ref. 3D-FU66533

Product Information

• Name: Umbelliferone-3-carboxylic acid
• Synonyms: 3-Carboxy-7-hydroxycoumarin, 2H-1-Benzopyran-3-carboxylic acid, 7-hydroxy-2-oxo-, 3-Carboxyumbelliferone, 7-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid, 7-Hydroxy-2-oxobenzopyran-3-carboxylic acid, 7-Hydroxycoumarin carboxylic acid, 7-Hydroxycoumarin-3-Carboxylic Acid, 7-Hydroxycoumarinyl-3-carboxylic acid, NSC 115545

Description

Umbelliferone-3-carboxylic acid is a reactive fluorescent probe that can be used to study the transfer reactions of disulfide bonds. It has a basic structure and biological properties similar to coumarin derivatives, and can be used as a fluorescent probe for studying protein folding and transfer reactions. In addition, Umbelliferone-3-carboxylic acid has been shown to react with human serum and form the reactive species 4-hydroxycinnamic acid. This reactive species reacts with DNA bases to form covalent adducts, which can be detected using fluorescence spectroscopy. Umbelliferone-3-carboxylic acid has also been shown to inhibit the growth of K562 cells in culture by binding covalently to DNA. The reactive species 4-hydroxycinnamic acid inhibits DNA replication by inhibiting rna synthesis.

• Brand: Biosynth

Chemical properties

• Molecular weight: 206.15 g/mol
• Formula: C₁₀H₆O₅
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C10H6O5/c11-6-2-1-5-3-7(9(12)13)10(14)15-8(5)4-6/h1-4,11H,(H,12,13)
• InChI key: InChIKey=LKLWLDOUZJEHDY-UHFFFAOYSA-N
• SMILES: O=C(O)c1cc2ccc(O)cc2oc1=O