Z-Val-Ala-OMe
CAS: 4817-92-9
Ref. 3D-FV111527
| 5g | 317.00 € | ||
| 10g | 460.00 € | ||
| 25g | 877.00 € | ||
| 50g | 1,402.00 € | ||
| 100g | 2,439.00 € |
Product Information
- methyl N-[(benzyloxy)carbonyl]valylalaninate
Z-Val-Ala-OMe is an anti-leishmanial agent that has been shown to be a more efficient method for the treatment of leishmaniasis than current treatments. It inhibits the growth of Leishmania by inhibiting serine proteases, which are involved in the formation of amorphous material on the surface of these parasites. Z-Val-Ala-OMe is active against both subtilis and licheniformis, with a residue half life of 3 hours at pH 5.5 and 20 degrees Celsius. This drug binds to the surface of Leishmania parasites and inhibits their ability to metabolize phosphite into ethyl esters.
The kinetic data obtained from Z-Val-Ala-OMe was measured using immobilized cells in a microtiter plate assay system. The data collected was used to generate a graph showing an initial burst phase followed by a linear phase for up to 72 hours post incubation with the drug
Chemical properties
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