Product Information
- 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-, methyl ester, (3S,4S)-
- Pyrophaeophorbide-a-monomethyl ester
- Methyl 4-(9-Ethenyl-14-Ethyl-4,8,13-Trimethyl-20-Oxophorbin-3-Yl)Butanoate
- Methyl 3-(9-Ethenyl-14-Ethyl-4,8,13,18-Tetramethyl-20-Oxo-24,25-Dihydrophorbin-3-Yl)Propanoate
- Methyl pyropheophorbide-a
Pyropheophorbide a methyl ester is an organic compound that is used in photodynamic therapy. It binds to hemoglobin, which is the oxygen-carrying protein of red blood cells. The binding of pyropheophorbide a methyl ester to hemoglobin causes it to become unstable and break down into reactive molecules that are cytotoxic. The carbonyl group on this molecule also makes it a good substrate for ABCG2, which is a transporter protein found on the surface of cancer cells. This drug has shown success in treating prostate cancer cells and herpes simplex virus. Pyropheophorbide a methyl ester has been shown to produce tumour necrosis when irradiated with UVB light, by inducing apoptosis and inducing the production of reactive oxygen species.
Chemical properties
Technical inquiry about: 3D-GAA45367 Pyropheophorbide a methyl ester
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