Trans-4-hydroxy-lomustine
CAS: 56239-24-8
Ref. 3D-GCA23924
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued | ||
| 50mg | Discontinued | ||
| 100mg | Discontinued |
Product Information
Name:
Trans-4-hydroxy-lomustine
Synonyms:
- NSC 239717
- Urea, N-(2-chloroethyl)-N′-(trans-4-hydroxycyclohexyl)-N-nitroso-
- N-(2-Chloroethyl)-N′-(trans-4-hydroxycyclohexyl)-N-nitrosourea
- 1-(2-Chloroethyl)-3-(trans-4-hydroxycyclohexyl)-1-nitrosourea
- Urea, N-(2-chloroethyl)-N′-(4-hydroxycyclohexyl)-N-nitroso-, trans-
Description:
Trans-4-hydroxy-lomustine is a pyridinium salt of the anti-cancer drug lomustine, which is used to treat various types of cancers. It is administered orally and has been shown to have antitumour activity in animal studies. Trans-4-hydroxy-lomustine is metabolized by cytochrome P450 enzymes, including CYP2C8, CYP2C9, and CYP3A4. The major metabolites are monohydroxylated trans-4-hydroxy lomustine, which inhibits DNA synthesis and protein synthesis in cells. This drug also has stereoselective effects on tumor cells compared to normal tissue cells. Trans-4-hydroxy lomustine has high lipophilicity due to its quaternary ammonium group.
Notice:
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Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
249.69 g/mol
Formula:
C9H16ClN3O3
Purity:
Min. 95%
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HS code:
