BQ 788 sodium salt

CAS: 156161-89-6

Ref. 3D-GGA16189

Product Information

• Name: BQ 788 sodium salt
• Synonyms: <span class="text-smallcaps">D</smallcap>-Norleucine, N-[(cis-2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, monosodium salt, <span class="text-smallcaps">D</smallcap>-Norleucine, N-[N-[N-[(2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl]-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl]-, monosodium salt, cis-, <span class="text-smallcaps">D</smallcap>-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, monosodium salt, <span class="text-smallcaps">D</smallcap>-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, sodium salt (1:1), BQ-788, Sodium Salt, Bq 788, sodium (2R)-2-{[(2S)-2-({[(2R,6S)-2,6-dimethylpiperidin-1-yl]carbonyl}amino)-4,4-dimethylpentanoyl][1-(methoxycarbonyl)-D-tryptophyl]amino}hexanoate, sodium N-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]carbonyl}-4-methyl-L-leucyl-N-[(1R)-1-carboxylatopentyl]-1-(methoxycarbonyl)-D-tryptophanamide

Description

BQ 788 is an endothelin-A receptor antagonist. It binds to the endothelin-1 receptor and prevents it from binding to its natural ligand, endothelin-1. BQ 788 has been shown to reduce the cardiac effects of endothelin-1 and also inhibit the gene expression of endothelin-1 in human platelets by binding to a different site on the receptor. The pharmacological action of BQ 788 is thought to be due to its ability to inhibit the activity of cytosolic Ca2+ that is involved in cellular signaling pathways.

• Brand: Biosynth

Chemical properties

• Molecular weight: 663.79 g/mol
• Formula: C₃₄H₅₀N₅NaO₇
• Purity: Min. 95%