5(S),15(S)-Dihydroxy-6(E),8(Z),10(Z),13(E)-eicosatetraenoic acid

CAS: 82200-87-1

Ref. 3D-HDA20087

Product Information

• Name: 5(S),15(S)-Dihydroxy-6(E),8(Z),10(Z),13(E)-eicosatetraenoic acid
• Synonyms: (5S,6E,8Z,11Z,13E,15S)-5,15-Dihydroxy-6,8,11,13-eicosatetraenoic acid, (5S,6E,8Z,11Z,13E,15S)-5,15-dihydroxyicosa-6,8,11,13-tetraenoic acid, 5(S),15(S)-Dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic acid, 5,15-Di-HETE, 5,15-Dihete, 5,15-Dihydroxy-6,8,11,13-eicosatetraenoic acid, 5S,15S-Dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic acid, 6,8,11,13-Eicosatetraenoic acid, 5,15-dihydroxy-, (5S,6E,8Z,11Z,13E,15S)-, 6,8,11,13-Eicosatetraenoic acid, 5,15-dihydroxy-, (S-(R*,R*-(E,E,Z,Z)))-

Description

5(S),15(S)-Dihydroxy-6(E),8(Z),10(Z),13(E)-eicosatetraenoic acid is a metabolite of arachidonic acid that has been found to have chemotactic activity. It is activated by two enzymes, 5-lipoxygenase and 15-lipoxygenase, which convert it to leukotrienes. The synthesis of 5-hydroxyeicosatetraenoic acid (5HETE) is catalyzed by the enzyme cytochrome P450, and this reaction is inhibited by aspirin. The biosynthesis of 5-HETE is catalyzed by the enzyme dihydroxyeicosatetraenoic acid synthase (DHET). The biological effects of 5-HETE are due to its activation at the cell membrane; it binds to a receptor on the leukocyte surface and stimulates chemotaxis

• Brand: Biosynth

Chemical properties

• Molecular weight: 336.5 g/mol
• Formula: C₂₀H₃₂O₄
• Purity: Min. 95%