5(S),6(R)-Dihydroxy-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid
CAS: 82948-88-7
Ref. 3D-HDA94888
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Product Information
5(S),6(R)-Dihydroxy-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid (5,6-DHETE) is a metabolite of arachidonic acid. It is formed by the action of cytosolic 5-lipoxygenase on arachidonic acid and functions as an intermediate in the synthesis of leukotriene A4. This metabolite has been shown to induce chemotaxis of human leukocytes. 5,6-DHETE has also been shown to be a substrate for epoxide hydrolase and epoxide reductase, which converts it to its corresponding alcohols, 5,6-dihydroxyeicosatrienoic acid and 7,9,11,14-tetrahydroxyeicosatrienoic acid respectively. The enzyme epoxide hydrolase can be
Chemical properties
Technical inquiry about: 3D-HDA94888 5(S),6(R)-Dihydroxy-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid
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