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N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
CAS: 1357171-62-0
Ref. 3D-HEC17162
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Product Information
N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine (NBTZ) is a potent and selective inhibitor of human VEGF. It blocks the binding of VEGF to its receptor and reduces blood vessel growth in vitro. NBTZ is a methylated analog of 6-phenyl-3-[(pyridin-2-yl)amino]-1,2,4 triazine (PTAT). The selectivity for VEGF over other angiogenic factors was confirmed by assays with recombinant human proteins and by normalization of the data. Replicates were used to confirm reproducibility between experiments. NBTZ is a dry powder that can be diluted with water or DMSO for use in assays. The structure activity relationship was elucidated through luminescent and
Chemical properties
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