Product Information
- 5-(3-Aminophenyl)Oxazole
- Buttpark 43\57-51
3-(1,3-Oxazol-5-yl)aniline is an inhibitor of the enzyme phosphoglycerate dehydrogenase (PGDH), which catalyzes the oxidation of 2-phosphoglycerate to 3-phosphoglycerate. It binds to PGDH and slows down the formation of 3-phosphoglycerate, which inhibits the production of ATP. The binding site for 3-(1,3-oxazol-5-yl)aniline has been determined by X-ray crystallography and affinity measurements to be near a conserved amino acid residue in the active site. This inhibition prevents cancer cells from growing and dividing. 3-(1,3-Oxazol-5-yl)aniline has been shown to inhibit breast cancer cells in vitro with high affinity.
Chemical properties
Technical inquiry about: 3D-HGA83731 3-(1,3-oxazol-5-yl)aniline
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