Product Information
- 2-Amino-3-chloro-4-cyano-5-(trifluoromethyl)pyridine
- 2-Amino-3-chloro-5-(trifluoromethyl)-isonicotinonitrile
- 2-Amino-3-chloro-5-(trifluoromethyl)pyridine-4-carbonitrile
- 2-Amino-4-ethynylpyrimidine
- 2-Pyrimidinamine, 4-ethynyl-
- 4-(2-Phenylethynyl)Pyrimidin-2-Amine
- 4-(But-1-Ynyl)Pyrimidin-2-Amine
- 4-(Phenylethynyl)pyrimidin-2-amine
- 4-(Prop-1-yn-1-yl)pyrimidin-2-amine
- 4-(Prop-1-ynyl)pyrimidin-2-amine
- See more synonyms
- 4-ethynyl-2-Pyrimidinamine
Meridianin is a meridianin isolated from the marine sponge Meridion sp. It has been shown to have anti-tumor and anti-inflammatory effects, as well as inhibitory activity on kinases. There are two known analogues of Meridianin, namely 4-ethynylpyrimidin-2-amine and 4,4'-dichloro-6-(4-ethynylpyrimidin-2-amine). The former is an indole alkaloid that has been shown to be an inhibitor of the enzyme histone deacetylase (HDAC), which plays a key role in regulation of gene expression. A nitrosoarene derivative of Meridianin has also been reported to be an inhibitor of kinases.
Chemical properties
Technical inquiry about: 3D-HYB17518 4-ethynylpyrimidin-2-amine
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