Product Information
- (5R)-5-methyloctan-2-one
- (5S)-5-methyloctan-2-one
- 2-Octanone, 5-methyl-
- 5-Methyloctan-2-One
5-Methyl-2-octanone is a potent inhibitor of gram-negative bacteria. It has been shown to be effective against Escherichia coli, Salmonella enterica, and Pseudomonas aeruginosa. This compound has also been shown to have neurotoxic effects in rats, but not in mice. The toxicity of 5-methyl-2-octanone is due to its ability to inhibit fatty acid synthesis by binding to the acyl carrier protein (ACP) in the cytoplasmic membrane. This inhibition leads to an accumulation of free fatty acids that are then taken up by cells and esterified into lipids, leading to cell death. 5-Methyl-2-octanone can also inhibit lysine residues in proteins by forming covalent bonds with the lysine amino group. This activity may be responsible for its antibacterial efficacy as it prevents bacterial growth by interfering with protein synthesis.
Chemical properties
Technical inquiry about: 3D-ICA65467 5-Methyl-2-octanone
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